AWANDARE RESEARCH GROUP

The research group focuses on the biology and pathogenesis of Plasmodium falciparum malaria, including providing a better understanding of host immune responses and exploitation of parasite invasion mechanisms for vaccine development.

The Group is primarily active within the Cell and Immunology Lab.

ABOUT THE GROUP

The research group focuses on the biology and pathogenesis of Plasmodium falciparum malaria, including providing a better understanding of host immune responses and exploitation of parasite invasion mechanisms for vaccine development.

The group is investigating the impact of varying transmission intensity on innate and adaptive responses as well as parasite diversity and signatures of selection. The lab also studies the molecular mechanisms through which malaria parasites maintain their ability to invade red blood cells in semi-immune individuals residing in highly-endemic areas of Ghana. There is also work on characterizing the etiology of febrile illnesses and understanding the genetic basis of both infectious diseases and non-communicable diseases.

Lab applications employed include fluorescent microscopy, confocal microscopy, high through-put cytokines and antibody assays, cell culture and invasion assays, multi-color flow cytometry, quantitative real time PCR, protein expression and characterization, and high-performance computing for genomics.

Research in the group is supported by grants from the World Bank (Awandare), AAS/Wellcome Trust (Awandare, Amenga-Etego, Amlabu, Aniweh, Bah), National Institutes of Health, USA (Awandare), Crick African Network/Research Council, UK (Bediako and Aniweh), Royal Society, UK (Awandare), Sanger Institute/National Institute of Health Research, UK (Awandare and Amenga-Etego), TIBA partnership – University of Edinburgh/ National Institute of Health Research, UK (Awandare, Aniweh, Amlabu, Mutungi, Mensah-Brown, and Amegatcher)

LATEST NEWS FROM THE AWANDARE RESEARCH GROUP

NewsWACCBIP Admin
The inaugural West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) Biotech Innovation and Entrepreneurship Training Boot Camp, a collaborative effort between WACCBIP, University of G...

NewsWACCBIP Admin
 The West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) has kicked off an intensive week-long hands-on training workshop on flow cytometry, an essential technique in modern bi...

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The West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) is pleased to announce that the University of Ghana has been awarded two, out of eight fellowships, to leading African scient...

Prof. Gordon Awandare

Group Leader

Group Members

The research group comprises PhD level researchers with immense expertise in various fields

Dr. Lucas Amenga-Etego

Lead, Genomics & Bioinformatics

Dr. Prosper Kanyong

Lead, Molecular Diagnostics

Dr. Yaw Aniweh

Lead, Cell & Molecular Biology

Dr. Yaw Bediako

Lead, Immunology & Pathogenesis

Dr. Emmanuel Amlabu

Lead, Biophysics & Proteomics
Research in the group is supported by grants from:
  • The World Bank (Awandare)
  • AAS/Wellcome Trust (Awandare, Amenga-Etego, Amlabu, Aniweh)
  • National Institutes of Health, USA (Awandare)
  • Crick African Network/Research Council, UK (Bediako, Amlabu and Aniweh)
  • Royal Society, UK (Awandare)
  • Sanger Institute/National Institute of Health Research, UK (Awandare and Amenga-Etego)
  • TIBA partnership – University of Edinburgh/ National Institute of Health Research, UK (Awandare, Aniweh, Amlabu, Mutungi, Mensah-Brown, and Amegatcher)
  1. Adadey, S. M., Esoh, K. K., Quaye, O., Amedofu, G. K., Awandare, G. A., & Wonkam, A. (2020). GJB4 and GJC3 variants in non-syndromic hearing impairment in Ghana. Experimental Biology and Medicine (Maywood). Jun 11.153570220931053. doi: 10.117/1535370220931035.
  2. Amlabu, W. E., Antwi, C. A., Awandare, G. & Gwira, T. M. (2020). Elucidating the possible mechanism of action of some pathogen box compounds against Leishmania donovani. PLoS Negl Trop Dis. 14(4):e0008188 doi:10.1371/journal.pntd.0008188
  3. Kinyanjui, S., Fonn, S., Kyobutungi, C., Vicente-Crespo, M., Bonfoh, B., Ndungu, T., Sewankambo, N. K., Djimde, A. A., Gaye, O., Chirwa, T., Musenge, E., Elliot, A., Nakanjako, D., Chibanda, D., &  Awandare, G. (2020). Enhancing science preparedness for health emergencies in Africa through research capacity building. BMJ Global Health;5:e003072. doi:10.1136/bmjgh-2020-003072
  4. Aniweh, Y., Nyarko, P. B., Charles-Chess, E., Ansah, F., Osier, F. H. A., Quansah, E., Thiam, L. G., Kamuyu, G., Marsh, K., Conway, D. J., Tetteh, K. K. A., & Awandare, G. A. (2020). Plasmodium falciparum Merozoite Associated Armadillo Protein (PfMAAP) is apically localized in free merozoites and antibodies are associated with reduced risk of malaria. Front. Immunol. 11:505. doi: 10.3389/fimmu.2020.00505
  5. Amlabu, E., Ilani, P., Opoku, G., Nyarko, P. B., Quansah, E., Thiam, L. G., Anim M, Ayivor-Djanie R, Akuh O., Mensah-Brown, H., Rayner, J. C. & Awandare, G. A. (2020). Molecular Characterization and Immuno-Reactivity Patterns of a Novel Plasmodium falciparum Armadillo-Type Repeat Protein, PfATRP. Frontiers in Cellular and Infection Microbiology, 10:114. doi: 10.3389/fcimb.2020.00114
  6. Deletsu, S. D., Maina, E. K., Quaye, O., Ampofo, W. K., and Awandare, G. A., & Bonney EY (2020).  High resistance to reverse transcriptase inhibitors among persons infected with human immunodeficiency virus type 1 subtype circulating recombinant form 02_AG in Ghana and on antiretroviral therapy.  Medicine (Baltimore). 2020 Feb;99(7):e18777. doi: 10.1097/MD.0000000000018777
  7. Krampa, F. D., Aniweh, Y., Kanyong, P., & Awandare, G. A (2020).  Recent advances in the development of biosensors for malaria diagnosis. Sensors (Basel). 2020 Feb 1;20(3). pii: E799. doi: 10.3390/s20030799.
  8. Aniweh, Y., Suurbaar, J., Morang’a, C. M., Nyarko, P. B., Wright, K. E., Kusi, K. A., Ansah, F., Kyei-Baafour, E., Quansah. E., Asante, J., Thiam, L. G., Higgins, M. K., & Awandare, G. A (2020).  Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas. Scientific Reports 10: 1498 (2020). https://doi.org/10.1038/s41598-020-58300-3
  9. Adadey, S.M., Tingang Wonkam, E., Twumasi Aboagye, E., Quansah, D., Asante-Poku, A., Quaye, O., Amedofu, G.K., Awandare, G.A., Wonkam, A (2020). Enhancing Genetic Medicine: Rapid and Cost-Effective Molecular Diagnosis for a GJB2 Founder Mutation for Hearing Impairment in Ghana. Genes 2020, 11, 132.
  10. Nyarko, P.B., Tarr, S.J., Aniweh, Y. Stewart, L. B., Conway, D. J. & Awandare, G. A. (2020) Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch at the whole transcriptome level. Scientific Reports 10, 245 (2020) doi:10.1038/s41598-019-56386-y
  11. Thiam, L. G, Aniweh Y, Quansah, E. B, Donkor, J. K, Gwira, T. M, Kusi, KA, Niang M, & Awandare G. A (2020). Cell trace far-red is a suitable erythrocyte dye for multi-color Plasmodium falciparum invasion phenotyping assays.  Experimental Biology and Medicine (Maywood). 5:1535370219897393. doi: 10.1177/1535370219897393
  12. Umunnakwe, F. A, Idowu, E. T, Ajibaye, O, Etoketim, B, Akindele, S, Shokunbi A. O, Otubanjo O. A, Awandare G. A, Amambua-Ngwa A, & Oyebola KM (2019).  High cases of submicroscopic Plasmodium falciparum infections in a suburban population of Lagos, Nigeria.  Malaria Journal. 18(1):433. doi: 10.1186/s12936-019-3073-7
  13. Diakité S. A. S, Traoré K, Sanogo I, Clark TG, Campino S, Sangaré M, Dabitao D, Dara A, Konaté D. S, Doucouré F, Cissé A, Keita B, Doumbouya M, Guindo M. A, Toure M. B, Sogoba N, Doumbia S, Awandare G. A, Diakité M (2019).  A comprehensive analysis of drug resistance molecular markers and Plasmodium falciparum genetic diversity in two malaria endemic sites in Mali.  Malaria Journal. 18(1):361. doi: 10.1186/s12936-019-2986-5.
  14. Goodman, S. R., & Awandare, G. A. EBM and SEBM Inaugurates its African Global Editor and Office.  Experimental Biology and Medicine (Maywood). 244(18):1607. doi: 10.1177/1535370219891014
  15. Adadey, S. M., Manyisa, N., Mnika, K., De Kock, C., Nembaware, V., Quaye, S., Amedofu, G. K., Awandare, G. & Wonkam, A (2019). GJB2 and GJB6 mutations in non-syndromic childhood hearing impairment in Ghana. Frontiers in Genetics. 10: 841
  16. Mensah-Brown, H. E., Aspeling-Jones, H., Delimini, R. K., Asante, K. P., Amlabu, E., Bah, S. Y., Beeson, J. G., Wright, G. J., Conway, D. J., & Awandare, G. A (2019). Antibody reactivity to merozoite antigens in Ghanaian adults correlates with growth inhibitory activity against Plasmodium falciparum in culture, Open Forum Infectious Diseases, 6(7): July 2019, ofz254, https://doi.org/10.1093/ofid/ofz254
  17. Kotey, E., Lukosaityte, D., Quaye, O., Ampofo, W., Awandare, G., & Iqbal, M (2019).  Current and Novel Approaches in Influenza Management.  Vaccines (Basel). 2019 Jun 18;7(2). pii: E53. doi: 10.3390/vaccines702005
  18. Sangare M, Toure HB, Toure A, Karembe A, Dolo H, Coulibaly YI, Kouyate M, Traore K, Diakité SA, Coulibaly S, Togora A, Guinto CO, Awandare GA, Doumbia S, Diakite M, Geschwind DH (2019). Validation of two parent-reported autism spectrum disorders screening tools M-CHAT-R and SCQ in Bamako, Mali. eNeurologicalSci. 2019 Jun;15:100188. doi: 10.1016/j.ensci.2019.100188
  19. Aniweh Y, Nyarko PB, Quansah E, Thiam LG, Awandare GA (2019). SMIM1 at a glance; discovery, genetic basis, recent progress and perspectives. Parasite Epidemiol Control. 2019 May;5:e00101. doi: 10.1016/j.parepi.2019.e00101.
  20. Anabire NG, Aryee PA, Abdul-Karim A, Quaye O, Awandare GA, Helegbe GK (2019).  Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women. PLoS One. 2019;14(4):e0215550. doi: 10.1371/journal.pone.0215550
  21. Kengne-Ouafo, J. A., Sutherland, C. J., Binka, F. N., Awandare, G. A., Urban, B. C., & Dinko, B. (2019) Immune Responses to the Sexual Stages of Plasmodium falciparum Parasites.  Front Immunol. 2019 Feb 11;10:136. doi: 10.3389/fimmu.2019.00136.
  22. Anabire, N. G., Aryee, P. A., Abdul-Karim, A., Abdulai, I. B., Quaye, O., Awandare, G. A., & Helegbe, G. K. Prevalence of malaria and hepatitis B among pregnant women in Northern Ghana: Comparing RDTs with PCR (2019).  PLoS One. 2019 Feb 6;14(2): e0210365. doi: 10.1371/journal.pone.0210365.
  23. Tarr, S. J., Diaz-Ingelmo, O., Stewart, L. B., Hocking, S. E., Murray. L., Duffy, C. W., Otto, T. D., Chappel, L., Rayner, J. C., Awandare, G. A., & Conway, D. J. (2018). Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of malaria parasite Plasmodium falciparum. BMC Genomics. 19:894
  24. Bah, S. Y., Morang’a, C. M., Kengne-Ouafo, J. A., Amenga–Etego, L., & Awandare, G. A. (2018). Highlights on the application of genomics and bioinformatics in the fight against infectious diseases: Challenges and ppportunities in Africa. Front. Genet. 9:575. doi: 10.3389/fgene.2018.00575
  25. Oyebola, K. M., Aina, O. O., Idowu, E. T., Olukosi, Y. A, Ajibaye, O. S., Otubanjo, O. A., Awolola, T. S., Awandare, G. A., & Amambua-Ngwa, A. (2018). A barcode of multilocus nuclear DNA identifies genetic relatedness in pre- and post-Artemether/Lumefantrine treated Plasmodium falciparum in Nigeria. BMC Infectious Diseases. 18:392, https://doi.org/10.1186/s12879-018-3314-3
  26. Duffy, C. W., Amambua-Ngwa, A., Ahouidi, A. D., Diakite, M., Awandare, G. A., Ba, H., Tarr, S. J., Murray, L., Stewart, L. B., D’Allessandro, U., Otto, T. D., Kwiatkowski, D. P., & Conway, D. J. (2018). Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development. Scientific Report 8, Article number:15763
  27. Amoako, N., Duodu, S., Dennis, F. E., Bonney, J. H. K., Asante, K. P., Ameh, J., Mosi, L., Hayashi, T., Agbosu, E. E., Pratt, D., Operario, D. J., Fields, B., Liu, J., Houpt, E. R., Armah, G. E., Stoler, J. and Awandare, G. A. (2018). Detection of dengue virus among children with suspected malaria, Accra, Ghana. Emerging Infectious Diseases. 24(8):1544-1547. doi: 10.3201/eid2408.180341
  28. Tiburu, E. K., Issah, I., Darko, M., Armah-Sekum, R. E., Gyampo, S. O. A., Amoateng, N. K., Kwofie, S. K. & Awandare, G (2018).  Investigating the conformation of S100β protein under physiological parameters using computational modeling: A clue for rational drug design. Open Biomedical Engineering Journal. 12:36-50. doi: 10.2174/1874120701812010036. eCollection 2018.
  29. Hogarh, J. N., Agyekum, T. P., Bempah, C. K., Owusu-Ansah, E. D. J., Avicor, S. W., Awandare, G. A., Fobil, J. N., & Obiri-Danso, K (2018).  Environmental health risks and benefits of the use of mosquito coils as malaria prevention and control strategy. Malaria Journal. 17(1):265. doi: 10.1186/s12936-018-2412-4.
  30. Yaw, A., Prosper, K., Krampa, F. & Awandare, G. A (2018).  Local diagnostics kits for Africa being developed in Ghana. Nature. 559 (7713): 181. doi: 10.1038/d41586-018-05666-0.
  31. Dinko, B., Amakpa, E., Kweku, M., Amoah, P., Tampuori, J., Adjuik, M., Awandare, G. A., & Deitsch, K. W (2018). Plasmodium falciparum malaria cases detected for prompt treatment by rapid diagnostic tests in the Ho Teaching Hospital of the Volta Region of Ghana. Parasite Epidemiology and Control. 3(3):e00072. doi: 10.1016/j.parepi.2018.e00072.
  32. Partey, F. D., Castberg, F. C., Sarbah, E. W., Silk, S. E., Awandare, G. A., Draper, S. J., Opoku, N., Kweku, M., Ofori, M. F., Hviid, L., & Barfod, L.  (2018).  Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria. PLoS One. 2018 Jun 8;13(6): e0198371. doi: 10.1371/journal.pone.0198371.
  33. Anabire, N. G, Aryee, P. A., Addo, F., Anaba, F., Kanwugu, O. N., Ankrah, J., Awandare, G. A. & Helegbe, G. K. (2018). Evaluation of hematological indices of childhood illnesses in Tamale Metropolis of Ghana. Journal of Clinical and Laboratory Analysis. 2018 Jun 3:e22582. doi: 10.1002/jcla.22582
  34. Abugri, J., Ansah, F., Asante, K. P., Opoku, C. N., Amenga-Etego, L. A. & Awandare, G. A.  (2018). Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana. African Academy of Sciences Open Research. DOI: 10.12688/aasopenres.12825.1
  35.  Amlabu, E., Mensah-Brown, H., Nyarko, P. B., Akuha, O., Opoku, G., Ilani P., Oyagbenro, R., Asiedu K., Aniweh, Y. & Awandare, G. A. (2018).  Functional characterization of Plasmodium falciparum surface related Antigen (PfSRA) as a potential blood-stage vaccine target. Journal of Infectious Diseases. 218 (5): 778–790. doi.org/10.1093/infdis/jiy222.
  36. Awandare, G.A., Nyarko, P. B., Aniweh, Y., Ayivor-Djanie, R., & Stoute, J. A. (2018).  Plasmodium falciparum strains spontaneously switch invasion phenotype in suspension culture. Scientific Reports. 8(1):5782. doi: 10.1038/s41598-018-24218-0.
  37. Dinko, B., Ansah, F., Agyare-Kwabi, C., Tagboto, S., Amoah, L., Urban, B., Sutherland, C., Williamson, K., Awandare, G., Binka, F., & Deitsch, K. (2018).  Gametocyte development and carriage in Ghanaian individuals with uncomplicated Plasmodium falciparum malaria. American Journal of Tropical Medicine & Hygiene. 99(1):57-64. doi: 10.4269/ajtmh.18-0077.
  38. Kanyong, P., Krampa, F., Aniweh, Y. & Awandare, G. (2018). Polydopamine-functionalized graphene nanoplatelet smart conducting electrode for bio-sensing applications. Arabian Journal of Chemistry. In press. DOI: 10.1016/j.arabjc.2018.01.001.
  39. Thomford, N. E., Dzobo, K., Yao N. A., Chimusa, E., Evans, J., Okai, E., Kruszka, P., Muenke, M., Awandare, G., Wonkam, A., & Dandara, C (2018).  Genomics and epigenomics of congenital heart defects: expert review and lessons learned in Africa. OMICS: A Journal of Integrative Biology. 2018 May;22(5):301-321. doi: 10.1089/omi.2018.0033
  40. Ademolue, T.W. & Awandare, G.A. (2018).  Evaluating anti-disease immunity to malaria and implications for vaccine design. Immunology. 153(4):423-434. doi: 10.1111/imm.12877.
  41. Adadey, S. M., Awandare, G., Amedofu, G. K., & Wonkam, A. (2017).  Public Health Burden of Hearing Impairment and the Promise of Genomics and Environmental Research: A Case Study in Ghana, Africa. OMICS: A Journal of Integrative Biology.  21(11): 638-646
  1. Chirawurah, D. J., Ansah, F., Nyarko, P. B., Duodu, S., Aniweh, Y., & Awandare, G. A. (2017). Antimalarial activity of Malaria Box compounds against Plasmodium falciparum clinical isolates. International Journal for Parasitology: Drugs and Drug Resistance. 7(3):399-406; doi:10.1016/j.ijpddr.2027.10.005
  2. Kusi K. A., Manu E. A., Manful Gwira T., Kyei-Baafour E., Dickson E. K., Amponsah J. A., Remarque E. J., Faber B. W., Kocken C. H. M., Dodoo D., Gyan B. A., Awandare G. A., Atuguba F, Oduro A. R., Koram K. A. (2017). Variations in the quality of malaria-specific antibodies with transmission intensity in a seasonal malaria transmission area of Northern Ghana. PLoS One. 12(9):e0185303. doi: 10.1371/journal.pone.0185303.
  3. Krampa, D. F., Aniweh, Y., Awandare, G. A., & Kanyong P. (2017). Recent progress in the development of diagnostic tests for malaria. Diagnostics, 7(3), 54; doi:10.3390/diagnostics7030054
  4. Kanyong, P., Krampa, F. D., Aniweh, Y. & Awandare, G. A. (2017).Enzyme-based amperometric galactose biosensors: a review. Microchimica Acta, DOI:10.1007/s00604-017-2465-z
  5. Anderson, D. E., Balapangu, S., Fleischer, H. N. A., Viade, R. A., Krampa, F. D., Kanyong, P., Awandare, G. A., & Tiburu, E. K. (2017). Investigating the Influence of Temperature on the Kaolinite-Base Synthesis of Zeolite and Urease Immobilization for the Potential Fabrication of Electrochemical Urea Biosensors, Sensors 2017, 17(8), 1831; doi:10.3390/s17081831
  6. Cissé, M., Awandare, G. A., Somé, F. A., Hayette, M., & Guiguemde, R. T. (2017). High concordance of Pfdhfr and Pfdhps genotypes between matched peripheral and placental isolates of delivered women in Bobo-Dioulasso, Burkina Faso. Annals of Parasitology, 63(2), 111–116. doi: 10.17420/ap6302.93
  7. Krampa, D. F., Aniweh, Y., Awandare, G. A., & Kanyong P. (2017). Disposable Amperometric Sensor Based on High-Performance PEDOT:PSS/Ionic Liquid Nanocomposite Thin Film-Modified Screen-Printed Electrode for the Analysis of Catechol in Natural Water Samples. Sensors, 17(8), 1716; doi:10.3390/s17081716
  8. Bakari, S. M., Ofori, J. A. Kusi, K. A., Aning, G. K., Awandare , G. A., Carrington, M., & Gwira, M. T. (2017). Serum biochemical parameters and cytokine profiles associated with natural African trypanosome infections in cattle. Parasites & Vectors. 10:312 DOI: 10.1186/s13071-017-2255-9
  9. Ademolue, T.W., Aniweh, Y., Kusi, K. A. & Awandare, G.A. (2017). Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity. Malaria Journal. 16:145
  10. Sam-Agudu N. A., Paintsil, E., Aliyu, M. H., Kwara, A., Ogunsola, F., Afrane, Y. A., Onoka, C., Awandare, G. A., Amponsah, G., Cornelius, L. J., Mendy, G., Sturke, R., Ghansah, A., Siberry, G. K., Ezeanolue E. E. (2016). Building Sustainable Local Capacity for Global Health Research in West Africa. Annals of Global Health, 82 (6). DOI:10.1016/j.aogh.2016.10.011
  11. Mensah-Brown, H. E., Abugri, J., Asante, K. P., Dwomoh, D., Dosoo, D., Atuguba, F., Conway, D. J. and Awandare, G. A (2017). Assessing the impact of differences in malaria transmission intensity on clinical and haematological indices in children with malaria. Malaria Journal, 16:96, DOI 10.1186/s12936-017-1745-8
  12. Azumah, B. K., Addo, P. G., Dodoo, A., Awandare, G., Mosi, L., Boakye, D. A., Wilson, M. D. (2017). Experimental demonstration of the possible role of Acanthamoeba polyphaga in the Infection and disease progression in Buruli ulcer (BU) using ICR Mice. Plos One, 12(3): e0172843
  13. Ademolue, T., Amodu, O., & Awandare, G. A. (2017). Sickle cell trait is associated with controlled levels of heme and mild pro-inflammatory response during acute malaria infection. Clinical & Experimental Immunology. Jan 31. doi: 10.1111/cei.12936
  14. Tiburu E. K., Mutocheluh, M., Arthur, P. K., Narkwa, P. W., Salifu, A. A., Agyei, M. A., Yeboah, R., Fleischer, H. N. A., Zhuang, J. and Awandare, G. (2017). Antifungal and anti-proliferative effects of Zeolites A and X on Yeast pathogenic and cancer cells in vitro. Journal of Biomaterials and Tissue Engineering. 7: 1–12.
  15. Tiburu E. K., Zhuang J., Fleischer H. N., Arthur P. K., Awandare G. A (2017). Expression, Purification, and Monitoring of Conformational Changes of hCB2 TMH67H8 in Different Membrane-Mimetic Lipid Mixtures Using Circular Dichroism and NMR Techniques. Membranes (Basel). 2017 Feb 17;7(1). pii: E10. doi: 10.3390/membranes7010010.
  16. Cisse, M., Awandare, G. A., Soulama, A., Tinto, H., Hayette, M. P., & Guiguemdé R. T. (2017). Recent uptake of intermittent preventive treatment during pregnancy with sulfadoxine–pyrimethamine is associated with increased prevalence of Pfdhfr mutations in Bobo‑Dioulasso, Burkina Faso. Malaria Journal, 16:38. DOI 10.1186/s12936-017-1695-1
  17. Stoler J. & Awandare G. A (2016). Febrile illness diagnostics and the malaria-industrial complex: a socio-environmental perspective. BMC Infectious Diseases. 2016 Nov 17;16(1):683.
  18. Cisse, M., Diallo, H. A., Some, A. D., Poda, A., Awandare, G. A., & Guiguemde, R. T (2016). Association of placental Plasmodium falciparum parasitaemia with maternal and newborn outcomes in the periurban area of Bobo-Dioulasso, Burkina Faso. Parasitology Open, 2: e15; 1-8
  19. Dinko, B., Ayivor-Djanie, R., Abugri, J., Agboli, E., Kye-Duodu, G., Tagboto, S., Tampuori, J., Adzaku, F., Binka, F. N., & Awandare, G. A (2016). Comparison of malaria diagnostic methods in four hospitals in the Volta region of Ghana. Malaria World Journal. 7:5
  20. MalariaGEN Plasmodium falciparum Community Project (2016). Genomic epidemiology of artemisinin resistant malaria. eLife 2016;5:e08714. DOI: http://dx.doi.org/10.7554/eLife.08714
  21. The West African Merozoite Invasion Network (WAMIN): (in alphabetical order): Ahouidi A. D., Amambua-Ngwa A., Awandare, G. A., Bei A. K., Conway D. J., Diakite M., Duraisingh M. T., Rayner J. C., Zenonos Z. A (2016). Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity. Trends Parasitology. 2016 Apr;32(4):274-83. doi: 10.1016/j.pt.2015.11.009. Epub 2015 Dec 23. Review
  22. Duffy, C. W., Assefa, S. A., MacInnis, B., Abugri, J., Amoako, N., Owusu-Agyei, S., Anyorigiya, T., Kwiatkowski, D. P., Conway, D. J. & Awandare, G. A. (2015). Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity. BMC Genomics. 16:527.
  23. Bowyer, P. W., Stewart, L. B., Aspeling-Jones, H., Mensah-Brown, H. E., Ahouidi, A. D., Amambua-Ngwa, A., Awandare, G. A., & Conway, D. J. (2015). Variation in Plasmodium falciparum Erythrocyte Invasion Phenotypes and Merozoite Ligand Gene Expression across Different Populations in Areas of Malaria Endemicity. Infection and Immunity. 83(6):2575-82.
  24. Mensah-Brown, H. E., Amoako, N., Abugri, J., Stewart, L. B., Agongo, G., Dickson, E. K., Ofori, M. F., Stoute, J. A., Conway, D. J., & Awandare, G. A. (2015). Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana. Journal of Infectious Diseases. 212(8):1288-97
  25. Stoler, J., Delimini, R. K., Bonney, K. J.H., Oduro, A. R., Owusu-Agyei, S., Fobil, J. N., & Awandare, G. A. (2015). Evidence of recent Dengue exposure among malaria parasite-positive children in three urban centers in Ghana. American Journal of Tropical Medicine and Hygiene. 92(3):497-500
  26. Amoako, N., Asante, K. P., Adjei, G., Awandare, G. A., Bimi, L., & Owusu-Agyei, S. (2014). Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana. PLoS One. 9(12).
  27. Stoler, J., Dashti, R. A.., Anto, F., Fobil, J. N., & Awandare, G. A. (2014). Deconstructing "malaria": West Africa as the next front for dengue fever surveillance and control. Acta Tropica. 134, 58-65
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  30. Boeuf, P. S., Loizon, S., Awandare, G. A., Tetteh, J. K., Addae, M. M., Adjei, G. O., Goka, B., Kurtzhals, J. A., Puijalon, O., Hviid, L., Akanmori, B. D., & Behr, C. (2012). Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia. Malaria Journal. 11(1):253.
  31. Awandare, G. A., Kempaiah, P., Ochiel, D. O., Piazza, P., Christopher, C.K., & Perkins, D. J. (2011). Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro American Journal of Hematology. 86(2):155-62.
  32. Awandare, G. A., Spadafora, C., Moch, K. J., Dutta, S., Haynes, J. D., & Stoute, J. A. (2011). Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes. Molecular & Biochemical Parasitology. 177(1):57-60.
  33. Spadafora, C., Awandare, G. A., Kopydlowski, K. M., Czege, J., Moch, K. J., Finberg, W. R., Tsokos, G. C. & Stoute.J. A. (2010). Complement receptor 1 is a sialic acid independent erythrocyte receptor of Plasmodium falciparum. PLoS Pathogens. 6(6).
  34. Awandare, G. A., Martinson, J. J., Were, T., Ouma, T, Davenport, G. C., Ong’echa, J. M., Wang, W. K., Leng, L., Ferrell, R. E., Bucala, R., & Perkins, D. J. (2009). Macrophage migration inhibitory factor (MIF) promoter polymorphisms and susceptibility to severe malarial anemia. Journal of Infectious Diseases. 200(4): 629-637.
  35. Keller, C. C., Ouma, C., Ouma, Y., Awandare, G. A., Davenport, G. C., Were, T., Hittner, J. B., Vulule, J. M., Ong’echa, J. M., & Perkins, D. J. (2009). Suppression of a novel hematopoietic mediator in children with severe malarial anemia. Infection and Immunity. 77(9):3864-71.
  36. Were, T., Davenport, G. C., Ouma, Y. E., Hittner, B. J., Awandare, G. A., Otieno, M. F., Ouma, C., Orago, A. S., Vulule, J. M., Ong’echa, J. M., & Perkins, D. J. (2009). Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism. Microbes and Infection. 11(8-9):811-9.
  37. Ouma, C., Davenport, G. C., Awandare, G. A., Keller, C. C., Were, T., Otieno, M. F., Vulule, J. M., Martinson, J., Ong’echa, J. M., Ferrell, R. E., & Perkins, D. J. (2008). Polymorphic Variability in the Interleukin (IL)-1beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1beta Production. Journal of Infectious Diseases. 198(8):1219-26.
  38. Ong’echa, J. M, Remo, A. M., Kristoff, J, Hittner, J. B., Were, T., Ouma, C., Otieno, R. O., Vulule, J. M, Keller, C. C., Awandare, G. A. & Perkins, D. J. (2008). Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10. Clinical Immunology. 126(2):211-21.
  39. Helegbe, G. K., Goka, B. Q., Kurtzhals, J. A. L., Addae, M. M., Ollaga, E., Tetteh, J. K. A., Dodoo, D., Ofori, M., Hirayama, K., Awandare, G. A., & Akanmori, B. D. (2007). Complement activation in Ghanaian children with Severe Plasmodium falciparum Malaria Journal. 6:165.
  40. Awandare, G. A., Kremsner, P. G., Hittner, J. B., Keller, C. C., Clark, I. A., Weinberg, J. B., & Perkins, D. J. (2007). Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria. American Journal of Tropical Medicine and Hygiene. 76(6): 1033-1036.
  41. Awandare, G. A., Ouma, Y., Ouma, C., Were, T., Otieno, R.,Keller, C. C., Davenport, G. C., Hittner, J. B., Vulule, J., Ferrell, R., Ong’echa, J. M., & Perkins, D. J. (2007). Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia. Infection and immunity. 75(1): 201-210.
  42. Awandare, G. A., Goka, B., Boeuf, P., Tetteh, J. K. A., Kurtzhals, J. A. L., Behr, C., & Akanmori, B. D. (2006). Increased levels of inflammatory mediators in children with severe Plasmodium falciparum malaria with respiratory distress. Journal of Infectious Diseases. 194 (10): 1438-1446.
  43. Awandare, G. A., Ouma, C., Keller, C. C., Were, T., Otieno, R., Ouma, Y., Davenport, D. C., Hittner, J. B., Vulule, Ong’echa, J. M., Ferrell, R., & Perkins, D. J. (2006). A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria. Genes and Immunity. 7(7):568-575.
  44. Awandare, G. A., Hittner, J. B., Kremsner, P. G., Ochiel, D. O., Keller, C. C., Weinberg, J. B., Clark, I. A., & Perkins, D. J. (2006). Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum Clinical Immunology. 119: 219-225.
  45. Ochiel, D. O., Awandare, G. A., Keller, C. C., Hittner, J. B., Kremsner, P. J., Weinberg, J. B., & Perkins, D. J. (2005). Differential regulation of β-chemokines in children with acute Plasmodium falciparum Infection and Immunity. 73(7): 4190-7.

 

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In response to the World Bank’s call for proposals for African Centres of Excellence, the University of Ghana proposed the establishment of the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) at Legon.

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